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At 68 weeks, average body weight loss was 16.6% (95% CI -17.1 to -16.0)

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Janumet - Clinical Pharmacology 12.1 Janumet Mechanism of Action JANUMET JANUMET combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin HCl, a member of the biguanide class